李冬妹

學(xué)位:博士研究生
職稱:教授
研究領(lǐng)域:生物化學(xué)與分子生物學(xué)-1)卡波氏肉瘤相關(guān)皰疹病毒致病機(jī)制及靶向遞藥研究;2)胃癌早期診斷與個體化診療研究。
郵箱:lidong_abc@126.com
通訊地址:石河子大學(xué)醫(yī)學(xué)院杏一樓辦公室603號
學(xué)術(shù)兼職情況:
高等醫(yī)藥院校一流課堂設(shè)計與實踐聯(lián)盟理事
(高等學(xué)校國家級實驗教學(xué)示范中心聯(lián)席會)
科研學(xué)術(shù)工作經(jīng)歷與教育背景:
1997.9-2002.7 石河子大學(xué)醫(yī)學(xué)院臨床醫(yī)學(xué)專業(yè),學(xué)士學(xué)位
2002.9-2005.7 石河子大學(xué)醫(yī)學(xué)院生物化學(xué)與分子生物學(xué)專業(yè),碩士學(xué)位
2009.9-2012.7 北京大學(xué)醫(yī)學(xué)部生物化學(xué)與分子生物學(xué)專業(yè),博士學(xué)位
2015.12-2016.03,美國內(nèi)布拉斯加州大學(xué)醫(yī)學(xué)中心,訪問學(xué)者
2016.07-2017.08,美國內(nèi)布拉斯加州大學(xué)林肯分校 博士后
2005.9-至今 就職于石河子大學(xué)醫(yī)學(xué)院 負(fù)責(zé)教學(xué)科研工作
科研項目:
1. 國家自然科學(xué)基金項目(編號32460038),2025-2028,32萬。(國家級核心項目)
2. 國家自然基金:長鏈非編碼RNA PVT1通過真核起始因子EIF4A1促進(jìn)胃癌侵襲轉(zhuǎn)移的作用和機(jī)制研究(編號82160573),2022-2025,34.1萬。(國家級核心項目)
3. 國家自然基金項目(編號81760362),2018-2021,33萬。(國家級核心項目)
4. 兵團(tuán)科技合作計劃項目(編號2022BC002),2022-2024,93萬。(自治區(qū)級)
5. 兵團(tuán)應(yīng)用基礎(chǔ)研究項目(編號2015AG015),2015-2019,30萬。(自治區(qū)級)
6. 石河子大學(xué)國際合作項目(編號GJHZ202102),2022-2024,15萬。(校級)
學(xué)術(shù)論文(15篇代表作):
1.Dongmei Li*. miR-769-3p inhibits cellular proliferation of KSHV-infected SH-SY5Y cells through targeting mTOR. Journal of cancer, 2024; 15(11): 3338-3349.(SCI,收錄)
2.Dongmei Li*. Folate-Targeted Nanocarriers Co-Deliver Ganciclovir and miR-34a-5p for Combined Anti-KSHV Therapy. Int. J. Mol. Sci. 2024, 25, 2932.(SCI,收錄)
3.Dongmei Li*. Targeted delivery of miR-34a-5p by phenylborate-coupled polyethylenimide nanocarriers for anti-KSHV treatment. Frontiers in Bioengineering and Biotechnology, 2024,11:1-12. (SCI,收錄)
4.Dongmei Li*.Eukaryotic translation initiation factor 4A1 in the pathogenesis and treatment of cancers. Frontiers in molecular biosciences. 2023(11):1-9. (SCI,收錄)
5.Dongmei Li*. An Essential Role of c-Fos in Notch1-Mediated Promotion of Proliferation of KSHV-Infected SH-SY5Y Cells. Current Molecular Pharmacology.2024,17: 1874. (SCI,收錄)
6.Dongmei Li*. Exploring the molecular landscape of osteosarcoma through PTTG family genes using a detailed multi-level methodology. Frontiers in Genetics, 2024.1431668. (SCI,收錄)
7.Dongmei Li*. Delivery of miR-34a-5p by Folic Acid Modified β-cyclodextrin Grafted Polyethylenimine Copolymer Nanocarriers to Resist KSHV. ACS Applied Nano Materials. 2023, 6, 10826-10836. (SCI,收錄)
8.Dongmei Li*. Eukaryotic translation initiation factor4A1 in the pathogenesis and treatment of cancers. Frontiers in molecular biosciences. 2023(11):1-9. (SCI,收錄)
9.Dongmei Li*. Kaposi’s sarcoma-associated herpesvirus infection promotes proliferation of SH-SY5Y cells by the Notch signaling pathway. Cancer Cell Int. (2021) 21:577.(SCI,收錄)
10.Dongmei Li*. HPV16 E6 gene polymorphisms and the functions of the mutation site in cervical cancer among Uygur ethnic and Han nationality women in Xinjiang, China. Cancer Cell International (2022) 22:94. (SCI,收錄)
11.Dongmei Li*. Study of miR-34a-5p inhibiting the malignant progression of KSHV-infected SH-SY5Y cells by targeting c-fos. Peer J (2022):13233.(SCI,收錄)
12.Dongmei Li*. Bone Marrow Derived SH-SY5Y Neuroblastoma Cells Infected by Kaposi’s Sarcoma Herpes Virus (KSHV) Display Unique Infection Phenotypes and Growth Properties. J Virol,2021,95(13):e00003-21.(SCI,收錄)
13.Dongmei Li*. Parthenolide inhibits proliferation of cells infected with Kaposi’s sarcomaassociated herpesvirus by suppression of the NFκB signaling pathway,Archives of Virology (2023) 168:39.(SCI,收錄)
14.Dongmei Li*. Analysis of genetic variation in human papillomavirus type 16 E1 and E2 in women with cervical infection in Xinjiang, China. BMC Medical Genomics (2021) 14:268.(SCI,收錄)
15.Dongmei Li*. High Expression of long non-coding RNA PVT1 predicts metastasis in Han and Uygur Patients with Gastric Cancer in Xinjiang, China. Scientific Reports. 2019(9):548-559.(SCI,收錄)
獲獎:石河子大學(xué)學(xué)科帶頭人,優(yōu)秀青年教師,“3152”青年骨干教師,石河子大學(xué)優(yōu)秀碩士論文指導(dǎo)教師,全國大學(xué)生基礎(chǔ)醫(yī)學(xué)創(chuàng)新研究暨實驗設(shè)計大賽優(yōu)秀指導(dǎo)教師,國家級大學(xué)生優(yōu)秀項目指導(dǎo)教師,石河子大學(xué)優(yōu)秀工會積極分子,石河子大學(xué)醫(yī)學(xué)院“優(yōu)秀共產(chǎn)黨員”等稱號。指導(dǎo)學(xué)生獲得指導(dǎo)學(xué)生參加全國大學(xué)生基礎(chǔ)醫(yī)學(xué)創(chuàng)新研究大賽獲國家級銀獎、銅獎各一項,省級二等獎三項。獲得石河子大學(xué)教學(xué)成果二等獎。參與獲得省級科技進(jìn)步獎二等獎1項,三等獎1項,石河子大學(xué)教學(xué)成果一等獎和研究生教學(xué)成果二等獎各1項。
承擔(dān)教學(xué):承擔(dān)本科生《生物化學(xué)》《Biochemistry》課程的教學(xué),研究生《醫(yī)學(xué)生物化學(xué)與分子生物學(xué)》《現(xiàn)代細(xì)胞與組化技術(shù)》等課程的教學(xué)。