崔曉賓 導(dǎo)師簡(jiǎn)介
一、照片
二、姓名：崔曉賓
三、性別：男
三、出生年月：1983年7月25日
五、學(xué)位、學(xué)歷：醫(yī)學(xué)博士、博士研究生
六、職稱：副教授
七、學(xué)術(shù)兼職情況
中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)泌尿男生殖系統(tǒng)學(xué)組委員
中國(guó)抗癌協(xié)會(huì)病理專委食管癌協(xié)作組委員
中國(guó)老年醫(yī)學(xué)學(xué)會(huì)病理分會(huì)青年委員會(huì)委員
中華醫(yī)學(xué)會(huì)病理分會(huì)會(huì)員
新疆病理學(xué)分會(huì)會(huì)員
八、基本情況
崔曉賓，醫(yī)學(xué)博士，副教授，碩士生導(dǎo)師。2015年獲華中科技大學(xué)同濟(jì)醫(yī)院腫瘤學(xué)博士學(xué)位。主要從事醫(yī)學(xué)本科、研究生和留學(xué)生教學(xué)、科研及臨床病理診斷工作。研究方向?yàn)槟[瘤的病理診斷與分子診斷學(xué)研究、新疆地區(qū)食管癌發(fā)病機(jī)制研究。兼任中華醫(yī)學(xué)會(huì)病理學(xué)分會(huì)泌尿男生殖系統(tǒng)學(xué)組委員、中國(guó)抗癌協(xié)會(huì)病理專委食管癌協(xié)作組委員、中國(guó)老年醫(yī)學(xué)學(xué)會(huì)病理分會(huì)青年委員會(huì)委員，中華醫(yī)學(xué)會(huì)病理分會(huì)會(huì)員，新疆病理學(xué)分會(huì)會(huì)員。主持國(guó)家自然科學(xué)基金2項(xiàng)，兵團(tuán)應(yīng)用基礎(chǔ)研究，石河子大學(xué)杰出青年科技人才培育計(jì)劃項(xiàng)目等10項(xiàng)；參加“十一五”國(guó)家科技支撐計(jì)劃、國(guó)際交際合作等多項(xiàng)課題。在SCI收錄雜志或中文核刊公開發(fā)表論文60余篇，其中以第一作者/通訊作者在SCI收錄雜志發(fā)表論文22篇（其中JCR 1區(qū)7篇）。作為主要參與人獲得兵團(tuán)科技進(jìn)步一等獎(jiǎng)1項(xiàng)（排名第四）。出版專著2部（副主編1部），獲得國(guó)家發(fā)明專利3項(xiàng)。
主持課題：
PLCE1基因調(diào)控miR-106b~25基因簇宿主基因MCM7促進(jìn)食管鱗癌細(xì)胞增殖的作用及分子機(jī)制研究（國(guó)家自然科學(xué)基金 81760436，34萬(wàn)，2018/01-2021/12，主持）
PLCE1基因在NMBA誘導(dǎo)小鼠食管上皮惡變中的作用及機(jī)制研究（石河子大學(xué)國(guó)際科技合作推進(jìn)計(jì)劃項(xiàng)目 GJHZ201702，30萬(wàn)，2018/01-2020/12，主持）
PLCE1基因調(diào)控炎性NF-кB信號(hào)通路在新疆哈族食管癌侵襲轉(zhuǎn)移中的作用與機(jī)制研究（國(guó)家自然科學(xué)基金 81460362，47萬(wàn)，2015/01-2018/12，主持）
PLCE1負(fù)性調(diào)控p53抑制新疆哈族食管癌細(xì)胞自噬的作用機(jī)制研究（兵團(tuán)應(yīng)用基礎(chǔ)研究計(jì)劃項(xiàng)目2016AG020，30萬(wàn)，2016/01 -2018/12，主持）
PLCE1基因?qū)κ彻馨┘?xì)胞自噬的作用研究（石河子大學(xué)高層次人才科研啟動(dòng)項(xiàng)目，RCZX201533，5萬(wàn)，2016/01-2018/12，主持）
PLCE1基因?qū)κ彻馨┘?xì)胞自噬抑制的作用機(jī)制初步研究（石河子大學(xué)杰出青年培育項(xiàng)目，2015ZRKXJQ02，8萬(wàn)，2016/01 -2018/12，主持，已結(jié)題）
聯(lián)檢多種腫瘤相關(guān)自身抗體對(duì)新疆哈族食管癌早期診斷的評(píng)價(jià)和應(yīng)用研究（石河子大學(xué)重大科技攻關(guān)項(xiàng)目，gxjs2014-zdgg06，15萬(wàn)，2015/01 -2017/12，主持，已結(jié)題）
PLCE1及其不同突變體對(duì)新疆哈薩克族食管癌侵襲遷移的影響及作用機(jī)制（2014/01 -2015/12 石河子大學(xué)“優(yōu)秀青年科技人才培育計(jì)劃”聯(lián)合資助立項(xiàng)項(xiàng)目，2013ZRKXYQ-YD19，4萬(wàn)，主持，已結(jié)題）
發(fā)表文章：
Ningjing Zou#, Lan Yang#, Ling Chen#(共同第一作者), Tingting Li, Tingting Jin, Hao Peng, Shumao Zhang, Dandan Wang, Ranran Li, Chunxia Liu, Jinfang Jiang, Lianghai Wang, Weihua Liang, Jianming Hu, Shugang Li, Chuanyue Wu, Xiaobin Cui,* Yunzhao Chen,* Feng Li*(共同通訊作者). Heterozygote of TAP1 Codon637 decreases susceptibility to HPV infection but increases susceptibility to esophageal cancer among the Kazakh populations. Journal of Experimental & Clinical Cancer Research, 2015, 34(1):70. (SCI, IF=6.451)
Cui X, Chen X, Wang W, Chang A, Yang L, Liu C, Peng H, Wei Y, Liang W, Li S, Wang N, Liu W, Hu J, Zhang W, Wang L, Chen Y, Li F(通訊作者). Epigenetic silencing of miR-203 in Kazakh patients with esophageal squamous cell carcinoma by MassARRAY spectrometry. Epigenetics, 2017, 12(8):698-707. (SCI, IF=4.9)
Xiao-bin Cui, Hao Peng, Ran-ran Li, Jian-qin Mu, LanYang, NaLi, Chun-xia Liu, Jian-ming Hu, Shu-gang Li, Yutao Wei, Laibo-Yin,Hong Zhou, Feng Li,and Yun-zhao Chen*(通訊作者). MicroRNA-34a functions as a tumor suppressor by directly targeting oncogenic PLCE1 in Kazakh esophageal squamous cell carcinoma. Oncotarget, 2017,8(54),92454-92469 (SCI, IF=5.168)
Cui XB#, Li S#, Li TT#(共同第一作者), Peng H, Jin TT, Zhang SM, Liu CX, Yang L, Shen YY, Li SG, Li N, Li Y, Hu JM, Jiang JF, Suo J, Qi Y, Liang WH, Wang LH, Dang HW, Li L, Cao WW, Wei Y, Laibo-Yin, Wu CY, Yuan XL, Zhou H, Zheng Y, Chen YZ*, Li F*(共同通訊作者). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 2016, 7(2):1777-1795 (SCI, IF=6.3)
Xiao-Bin Cui*, Yan-Xia Tian*, Cai-Pu Chun*, Hao Peng, Chun-Xia Liu, Lan Yang, Jian-Ming Hu, Hua-Hua Xin, Xi Chen, Ning Wang, Yu-Tao Wei, Lai-Bo Yin, Yun-Zhao Chen, Feng Li. Genome-wide screening for genomic aberrations in Kazakh patients with esophageal squamous cell cancer by comparative genomic hybridization.Int J Clin Exp Pathol 2018;11(1):427-437
Xiaobin Cui#, Zhimin Zhao#(共同第一作者), Dong Liu, Tao Guo, Su Li, Jianming Hu, Chunxia Liu, Lan Yang, Yuwen Cao, Jinfang Jiang, Weihua Liang, Wei Liu, Shugang Li, Lianghai Wang, Lidong Wang, Wenyi Gu, Chuanyue Wu, Yunzhao Chen*, Feng Li*(共同通訊作者)Inactivation of miR-34a by aberrant CpG methylation in Kazakh patients with esophageal carcinoma. J Exp Clin Cancer Res. 2014, 33(1):20. (SCI, IF=4.451)
Xiao-bin Cui#, Yao-yuan Shen#, Tingting Jin# (共同第一作者), Su Li, Ting-ting Li, Shu-mao Zhang, Hao Peng, Jian-ming Hu, Chun-xia Liu, Lan Yang, Jing Jin, Jin-Fang Jiang, Wei-hua Liang, Na Li, Zhen-zhu Sun, Shu-gang Li, Chuan-yue Wu, Yun-zhao Chen,* Feng Li*(共同通訊作者). SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma. J Transl Med, 2015,13:321 (SCI, IF=3.947)
Cui XB#, Zhang SM#(共同第一作者), Xu YX, Dang HW, Liu CX, Wang LH, Yang L, Hu JM, Liang WH, Jiang JF, Li N, Li Y, Chen YZ*, Li F*(共同通訊作者). PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. J Transl Med. 2016, 14(1):137. (SCI, IF=3.947)
Cui X, Wang K, Yang X, Peng H, Chen X, Xin H, Tian Y, Chen Y, Li F. Comprehensive bioinformation analysis of the miRNA of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Cell Biochem, 2018,442(1-2):111-127.
Xiaobin Cui, Huahua Xin, Hao Peng and Yunzhao Chen*(通訊作者). Comprehensive bioinformatics analysis of the mRNA profile of PLCE1 knockdown in esophageal squamous cell carcinoma. Mol Med Rep, 2017,16(5):5871-5880. (SCI, IF=1.847)
Hao Peng, Jie Yu, Feng Li, Xiaobin Cui*(通訊作者), Yunzhao Chen*(通訊作者). Decreased vitamin D receptor protein expression is associated with the progression and prognosis of esophageal squamous cell carcinoma: a multi-ethnic cohort study from the Xinjiang, China. Int J Clin Exp Pathol, 2017, 10(2):2340-2350. (SCI, IF=2.242)
Xiao-Bin Cui#, Ran-Ran Li#, Xiao-Li Diao#(共同第一作者), Tao Ren, Hao Peng, Dan-Dan Wang, Bin Wang, Yun-Zhao Chen(通訊作者), Feng Li(通訊作者). Hypermethylation of RASSF1A CpG insland is associated with esophageal squamous cell carcinoma in Kazakh patients. Int J Clin Exp Pathol, 2017,10(2):1765-1773. (SCI, IF=2.242)
Xiao-Bin Cui#, Dan-Dan Wang#(共同第一作者), Hai-Yang Zhang, Ting-Ting Li, Ting-Ting Jin, Hao Peng, Shu-Mao Zhang, Bin Wang, Jie Yu, Chun-Xia Liu, Lan Yang, Jing Jin, Su Li, Jin-Fang Jiang, Wei-Hua Liang, Jian-Ming Hu, Shu-Gang Li, Chuan-Yue Wu, Yun-Zhao Chen*, Feng Li*(共同通訊作者). Tumor necrosis factor-α gene 308G/A polymorphism is not associated with esophageal squamous cell carcinoma risk in Kazakh patients. Int J Clin Exp Pathol, 2015, 8(8):9293-9299 (SCI, IF=2.242)
Xiaobin Cui#, Hao Peng #,(共同第一作者), Jing Jin, Tingting Li, Shumao Zhang, Tingting Jin, Su Li, Chunxia Liu, Weihua Liang, Feng Li, Yunzhao Chen*. RANK overexpression as a novel esophageal cancer marker: validated immunohistochemical analysis of two different ethnicities. Int J Clin Exp Pathol 2015;8(2):2249-2258.
Dong HC#, Cui XB#, Wang LH #(共同第一作者), Li M, Shen YY, Zhu JB, Li CF, Hu JM, Li SG, Yang L, Zhang WJ, Chen YZ, Li F. Type-specific detection of human papillomaviruses in Kazakh esophageal squamous cell carcinoma by genotyping both E6 and L1 genes with MALDI-TOF mass spectrometry. Int J Clin Exp Pathol. 2015, 8(10):13156-65
Man Li#, Xiaobin Cui#(共同第一作者), Yaoyuan Shen, Hongchao Dong, Weihua Liang, Yunzhao Chen, Jianming Hu, Shugang Li, Jing Kong, Hongan Li, Jin Zhao*, Feng Li*(共同通訊作者). ORAOV1 overexpression in esophageal squamous cell carcinoma and esophageal dysplasia: a possible biomarker of progression and poor prognosis in esophageal carcinoma. Human Pathology, 2015,46(5):707-715 (SCI, IF=2.769)
Xiao-bin Cui#, Xue-lian Pang#(共同第一作者), Su Li, Jing Jin, Jian-ming Hu, Lan Yang, Chun-xia Liu, Li Li, Shu Jun Wen, Wei-hua Liang, Yun-zhao Chen*, Feng Li*(共同通訊作者). Elevated expression patterns and tight correlation of the PLCE1 and NF-κB signaling in Kazakh patients with esophageal carcinoma. Medical oncology, 2014, 31(1):791. (SCI, IF=2.647)
Xiaobin Cui, Yunzhao Chen, Lin Liu, Li Li, Jianming Hu, Lan Yang, Weihua Liang, Feng Li*. Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations. J Med Virol. 2014, 86(4):608-17 (SCI, IF=2.3)
Xiao-Bin Cui, Yun-Zhao Chen, Xue-lian Pang, Wei Liu, Jian-Ming Hu, Shu-Gang Li, Lan Yang, Wen-Jie Zhang, Chun-xia Liu, Yu-wen Cao, Jin-Fang Jiang, Wen-Yi Gu, James Pang, Lei Yang, Xiang-Lin Yuan, Shi-Ying Yu, Feng Li*. Multiple polymorphisms within the PLCE1are associated with esophageal cancer via promoting the gene expression in a Chinese Kazakh population. GENE, 2013,530(2),315–322 (SCI, IF=2.196)
Xiaobin Cui #, Su Li #(共同第一作者), Xuelian Pang, Jing Jin, Jianming Hu, Chunxia Liu, Lan Yang, Jinfang Jiang, Weihua Liang, Jing Suo, Yunzhao Chen*，F(xiàn)eng Li*(共同通訊作者). Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol.2014,7(4),2382-2391 (SCI, IF=2.242)
Xiao-Bin Cui #, Jing Jin #(共同第一作者), Xue-Lian Pang, Su Li, Chun-Xia Liu, Ting-Ting Li, Hao Peng, Shu-Mao Zhang, Li Li, Wei-Hua Liang, Yunzhao Chen*，F(xiàn)eng Li*(共同通訊作者). A case of blastic plasmacytoid dendritic cell neoplasm with ecchymotic lesions on the whole body. Int J Clin Exp Pathol, 2014;7(7):4391-4399 (SCI, IF=2.242)
Xiao-Bin Cui, Hao Peng, Su Li, Ting-ting Li, Shu-mao Zhang, Jian-ming Hu, Chun-xia Liu, Liang-hai Wang, Jing Suo, Na Li, Li Li, Wei-hua Liang, Yun-Zhao Chen*, Feng Li*(共同通訊作者). Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: A Systematic Review and Meta-Analysis. Asian Pac J Cancer Prev, 2014, 15 (22), 9661-9666 (SCI, IF=2.514)
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