肖晗

學(xué)位：博士研究生

職稱：研究員

研究領(lǐng)域：內(nèi)科學(xué)-炎癥與心血管重構(gòu)

郵箱：xiaohan@bjmu.edu.cn

通訊地址：石河子大學(xué)醫(yī)學(xué)院杏1樓辦公室213號(hào)

學(xué)術(shù)兼職情況：

國際心臟研究會(huì)（ISHR）中國分會(huì)委員會(huì)副秘書長

中國藥理學(xué)會(huì)第十三屆全國心血管藥理專業(yè)委員會(huì)常務(wù)委員

中國藥理學(xué)會(huì)生化與分子藥理學(xué)專業(yè)委員會(huì)第七屆委員會(huì)委員

中華醫(yī)學(xué)會(huì)心血管病學(xué)分會(huì)第十一屆委員會(huì)基礎(chǔ)研究學(xué)組委員

中國病理生理學(xué)會(huì)心血管專業(yè)委員會(huì)青年委員

科研學(xué)術(shù)工作經(jīng)歷與教育背景：

        1998.9-2003.7 北京大學(xué)醫(yī)學(xué)部臨床醫(yī)學(xué)專業(yè)，學(xué)士學(xué)位

2003.9-2008.7 北京大學(xué)醫(yī)學(xué)部病理生理學(xué)專業(yè)，博士學(xué)位

2008.9-2010.1北京大學(xué)第三醫(yī)院血管醫(yī)學(xué)研究所研究助理

2010.2-2012.9美國加州大學(xué)河濱分校生物醫(yī)學(xué)系博士后

2012.12-2017.8北京大學(xué)第三醫(yī)院血管醫(yī)學(xué)研究所助理研究員

2017.8-2021.4北京大學(xué)第三醫(yī)院血管醫(yī)學(xué)研究所副研究員

2021.4-至今北京大學(xué)第三醫(yī)院血管醫(yī)學(xué)研究所研究員

科研項(xiàng)目：

1.國家自然科學(xué)基金面上項(xiàng)目（32371158），雌激素在交感應(yīng)激致心臟損傷中的保護(hù)作用及機(jī)制，2024/01-2027/12,50萬 課題負(fù)責(zé)人

2.國家自然科學(xué)基金重點(diǎn)項(xiàng)目（82030072），運(yùn)動(dòng)康復(fù)干預(yù)交感應(yīng)激致心臟損傷的作用及機(jī)制研究，2021/01-2025/12，297萬元，課題負(fù)責(zé)人

3.國家自然科學(xué)基金優(yōu)秀青年科學(xué)基金項(xiàng)目（81822003），炎癥與心血管重構(gòu)，2019/01-2021/12，130萬元， 課題負(fù)責(zé)人

4.國家自然科學(xué)基金面上項(xiàng)目（81670205），二甲雙胍抑制交感激活引起的心臟炎癥反應(yīng)的機(jī)制研究，2017.1-2020.12，60萬，課題負(fù)責(zé)人

5.國家自然科學(xué)基金青年基金項(xiàng)目（81300067），二甲雙胍抑制心臟纖維化的分子機(jī)制，2014.1-2016.12，23萬，課題負(fù)責(zé)人

6.國家重點(diǎn)研發(fā)計(jì)劃工程科學(xué)與綜合交叉專項(xiàng)“心肌纖維化演變機(jī)理探索與無創(chuàng)精準(zhǔn)影像評價(jià)體系構(gòu)建”項(xiàng)目，課題一“心肌纖維化發(fā)生與演變的機(jī)理和靶向分子探針研究”（2021YFF0501401），2021.12-2026.12 ，492.5萬，子課題負(fù)責(zé)人

7.國家重點(diǎn)研發(fā)計(jì)劃“發(fā)育編程及其代謝調(diào)節(jié)”專項(xiàng) （2023YFA1800902 to H.X）課題二“劇烈應(yīng)激反應(yīng)誘導(dǎo)心腦失能和猝死的分子與發(fā)育機(jī)制”課題，2024.01-2028.12，100萬，子課題研究骨干

8.國家重點(diǎn)研發(fā)計(jì)劃“主動(dòng)健康和老齡化科技應(yīng)對”重點(diǎn)專項(xiàng)“老年人多病共患臨床大數(shù)據(jù)綜合管理共享平臺(tái)建設(shè)及防治策略研究”項(xiàng)目(2020YFC2004704) 課題四“多病共患老年人危重癥發(fā)病預(yù)警和風(fēng)險(xiǎn)預(yù)測工具研發(fā)”，2020.7-2022.12，30萬，子課題研究骨干

學(xué)術(shù)論文：

1. Mingming Zhao #, Ning Cao #, Huijun Gu #, Jiachao Xu, Wenli Xu, Di Zhang, Tong-You Wade Wei, Kang Wang, Ruiping Guo, Hongtu Cui, Xiaofeng Wang, Xin Guo, Zhiyuan Li, Kangmin He, Zijian Li, Youyi Zhang, John Y-J Shyy, Erdan Dong*, Han Xiao*. AMPK Attenuation of β-Adrenergic Receptor-Induced Cardiac Injury via Phosphorylation of β-Arrestin-1-ser330. Circulation Research. 2024 Aug 30;135(6):651-667.

2. Xiangning Deng#, Hongtu Cui#, Hao Liang#, Xinyu Wang, Haiyi Yu, Jingjia Wang, Wenyao Wang, Dongyang Liu, Youyi Zhang, Erdan Dong*, Yida Tang*, Han Xiao* SARS-CoV-2 spike protein acts as a β-adrenergic receptor agonist: a potential mechanism for cardiac sequelae of long COVID. Journal of internal medicine. 2024;296:291–97.

3. Jimin Wu, Melody Shyy, John-Y-J. Shyy, and Han Xiao* Role of inflammasome in endothelial dysfunction. British journal of pharmacology. 2024 Jul 1. doi: 10.1111/bph.16479. Online ahead of print.

4. Haifan Wang; Xiaojun Du; Youyi Zhang; Han Xiao*. New perspective on the mechanisms of cardiac fibrosis. Sci Bull (Beijing). 2023 Nov 30;68(22):2704-2708.  

5. Kang Wang, Yawen Deng, Han Xiao*. Exercise and cardiac fibrosis. Current opinion in physiology, 2023, 31: 100630.

6. Mi Zhang, Akehu Alemasi, Mingming Zhao, Wenli Xu, Youyi Zhang, Wei Gao, Haiyi Yu*, Han Xiao* Exercise Training Attenuates Acute β-Adrenergic Receptor Activation-Induced Cardiac Inflammation via the Activation of AMP-Activated Protein Kinase，Int J Mol Sci . 2023 May 25;24(11):9263.doi: 10.3390/ijms24119263.

7. Di Zhang, Ming-Ming Zhao, Ji-Min Wu, Rui Wang, Gang Xue, Yan-Bo Xue, Ji-Qi Shao, You-Yi Zhang, Er-Dan Dong*, Zhi-Yuan Li*, and Han Xiao*.  Dual-omics reveals temporal differences in acute sympathetic stress-induced cardiac inflammation following α1 and β-adrenergic receptors activation, Acta Pharmacol Sin. 2023 Jul;44(7):1350-1365.

8. Xianda Chen, Shuaixing Wang, Wenli Xu, Mingming Zhao, Youyi Zhang, and Han Xiao*. Metformin Directly Binds to Mmp-9 to Improve Plaque Stability J Cardiovasc Dev Dis . 2023 Jan 30;10(2):54. https://dx.doi.org/10.3390/jcdd10020054.

9. Cong, Zhukai, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao*, and Xi Zhu*. α1-adrenoceptor stimulation ameliorates lipopolysaccharide-induced lung injury by inhibiting alveolar macrophage inflammatory responses through NF-κB and ERK1/2 pathway in ARDS, Frontiers In Immunology, 2022.13: 1090773.

10. Na Feng, Haiyi Yu, Yueshen Wang, Youyi Zhang, Han Xiao*, and Wei Gao*. Exercise Training Attenuates Angiotensin Ii-Induced Cardiac Fibrosis by Reducing Pou2f1 Expression.  Journal of Sport and Health Science  2023 Jul;12(4):464-476.

11. Guomin Hu, Jimin Wu, Huijun Gu, Xiangning Deng, Wenli Xu, Shan Feng, Shuaixing Wang, Yao Song, Zhengda Pang, Xiuling Deng, Aleksandr Vendrov, Nageswara Madamanchi, Marschall Runge, Xinyu Wang, Youyi Zhang, Han Xiao*, Erdan Dong. Galectin-3-Centered Paracrine Network Mediates Cardiac Inflammation and Fibrosis Upon β-Adrenergic Insult. Sci. China Life Sci. 2023 May;66(5):1067-1078.

12. Shuai-Xing Wang, Ye-Nan Feng, Shan Feng, Ji-Min Wu, Mi Zhang, Wen-Li Xu, You-Yi Zhang, Hai-Bo Zhu*, Han Xiao*, Er-Dan Dong  IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway. Acta Pharmacol Sin. 2022 Oct;43(10):2542-2549.

13. Yiqun Liu, Xiaojin Luo, Youyi Zhang, Zijian Li, Han Xiao*, and Yue Cui*. Electrochemical Protein-Based Biosensors for Creatine Kinase: A Review. IEEE SENSORS JOURNAL.2022 22(11): 10280-10291. https://doi.org/10.1109/JSEN.2022.3167415.

14. Jimin Wu, Erdan Dong, Youyi Zhang, and Han Xiao*, The Role of the Inflammasome in Heart Failure. Front. Physiol., 2021. 12:709703.

15. Lu Tie*, Han Xiao*, Da-Lei Wu*, Ye Yang, Pei Wang, A brief guide to good practices in pharmacological experiments: Western blotting. Acta Pharmacol Sin, 2021. 42(7): p. 1015-1017.

16. Ning Cao # , Jing-Jing Wang #, Ji-Min Wu , Wen-Li Xu , Rui Wang , Xian-da Chen , Ye-Nan Feng , Wen-Wen Cong , You-Yi Zhang *, Han Xiao*, Er-Dan Dong. Glibenclamide alleviates beta adrenergic receptor activation-induced cardiac inflammation. Acta Pharmacologica Sinica. 2022 May;43(5):1243-1250.  

17. Mingzhe Li, Jimin Wu, Guomin Hu, Yao Song, Jing Shen, Junzhou Xin, Zijian Li, Wei Liu, Erdan Dong, Ming Xu, Youyi Zhang*, Han Xiao*. Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway. Sci. China Life Sci. 2021. 64(2): p. 242-254.

18. Jing Shen#, Jimin Wu#, Guomin Hu, Mingzhe Li, Wenwen Cong, Yenan Feng, Shuaixing Wang, Zijian Li, Ming Xu, Erdan Dong, Youyi Zhang, Han Xiao*. Membrane nanotubes facilitate the propagation of inflammatory injury in the heart upon overactivation of the β-adrenergic receptor. Cell Death Dis. 2020 Nov 7;11(11):958. doi: 10.1038/s41419-020-03157-7.

19. WenliXu，Youyi Zhang，Han Xiao* AMP-activated protein kinase activation: therapeutic potential in human diseases. Science Bulletin, 2019. 64(18): p. 1303-1305.

20. Akehu Alemasi,Ning Cao, XiangboAn, Jimin Wu, Huijun Gu, Haiyi Yu, Yao Song, Huan Wang,Youyi Zhang, Han Xiao*,Wei Gao*. Exercise Attenuates Acute β-Adrenergic Overactivation-Induced Cardiac Fibrosis by Modulating Cytokines. J Cardiovasc Transl Res. 2019 Jun ;12:528–538.

21. Han Xiao#, Hao Li#, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang*. IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. European Heart Journal. 2018. Jan;39(1):60-69.

22. Jing Shen(#), Jiang-Hui Zhang(#), Han Xiao(#), Ji-Min Wu, Kang-Min He, Zhi-Zhen Lv, Zi-Jian Li, Ming Xu and You-Yi Zhang(*).Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis. Cell Death&Disease, 2018.1.23, 9(2): 81 

23. Ruifei Chen, Yenan Feng, Jimin Wu , Yao Song, Hao Li, Qiang Shen, Dan Li, Jianshu Zhang, Zhizhen Lu, Han Xiao*, Youyi Zhang*. Metformin attenuates angiotensin II-induced TGFbeta1 expression by targeting hepatocyte nuclear factor-4-alpha. British journal of pharmacology. 2018 Apr;175(8):1217-1229. 

24. Zhongcheng Xu, Jimin Wu, Junzhou Xin, Yenan Feng, Guomin Hu, Jing Shen, Mingzhe Li, Youyi Zhang, Han Xiao*, Li Wang*.β3-adrenergic receptor activation induces TGFβ1 expression in cardiomyocytes via the PKG/JNK/c-Jun pathway. Biochem Biophys Res Commun. 2018 Sep 3;503(1):146-151.

25. Yenan Feng, Shuaixing Wang, Youyi Zhang, Han Xiao*. Metformin attenuates renal fibrosis in both AMPKalpha2-dependent and independent manners. Clinical and experimental pharmacology & physiology. 2017. Jun;44(6):648-655.

26. Yenan Feng, Youyi Zhang, Han Xiao* AMPK and cardiac remodeling. Sci China Life Sci 2018; 61(1):14-23. doi: 10.1007/s11427-017-9197-5

27. Han Xiao, Jianshu Zhang, Zhonghe Xu, Yenan Feng, Mingliang Zhang, Jianli Liu, Ruifei Chen, Jing Shen, Jimin Wu, Zhizhen Lu, Xiaohong Fang, Jingyuan Li，Youyi Zhang. Metformin is a novel suppressor for transforming growth factor (TGF)-beta1. Scientific reports (2016);6:28597 

28. Jingjing Wang, Yao Song, Hao Li, Qiang Shen, Jing Shen, Xiangbo An, Jimin Wu, Jianshu Zhang, Yunong Wu, Han Xiao*, Youyi Zhang*. Exacerbated cardiac fibrosis induced by beta-adrenergic activation in old mice due to decreased AMPK activity.  Clin Exp Pharmacol Physiol (2016)43, 1029-1037.

29. Han Xiao, Min Lu, Ting Yang Lin, Zhen Chen, Gang Chen, Wei-Chi Wang，Traci Marin, Liang Wen, Brendan Gongol, Wei Sun, Ju Chen, Hsien-Da Huang， Joao H.F. Pedra, David A. Johnson, and John Y-J. Shyy. SREBP2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. Circulation (2013) 128(6), 632-642. 

獲獎(jiǎng)：

2021年11月  中源協(xié)和生命醫(yī)學(xué)獎(jiǎng)創(chuàng)新突破獎(jiǎng)

2020年11月  姜必寧獎(jiǎng)-杰出青年心臟醫(yī)師論文獎(jiǎng)

2017年11月  Young Investigator Award (poster presentation)美國心臟協(xié)會(huì)AHA 2017年會(huì)衛(wèi)星會(huì)China-USA Cardiovascular Symposium

2017年10月  中國藥理學(xué)會(huì)-施維雅青年藥理學(xué)家獎(jiǎng)

專利：

國內(nèi)專利：肖晗，張幼怡，李明喆 POU2F1基因表達(dá)抑制劑在制備治療組織纖維化疾病藥物中的應(yīng)用  2021. 發(fā)明專利  ZL 202010011105.2

國內(nèi)專利：張幼怡，肖晗，李明喆，馮曄囡 PAX6基因或其表達(dá)產(chǎn)物在制備抑制纖維化的藥物中的應(yīng)用 2021  發(fā)明專利 ZL 202010083224.9

國內(nèi)專利：肖晗，張幼怡，李明喆，胡國民  PAX4基因表達(dá)抑制劑在制備抑制纖維化的藥物中的應(yīng)用  2021  發(fā)明專利 ZL 202010115236.5

國內(nèi)專利：肖晗，張幼怡，王秀杰，馮姍，劉鑫一種用于抑制纖維化的小分子藥物及其應(yīng)用 2022 發(fā)明專利  ZL 202210436246.8

國內(nèi)專利：肖晗，張幼怡，王秀杰，馮姍，劉鑫一種用于抑制纖維化的小分子藥物及其應(yīng)用 2022 發(fā)明專利 ZL 202210436220.3